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Partha Majumder has made significant contributions to human-, statistical- and population genetics and genomics. He has developed methodologies for mapping human disease genes, identified genomic factors underlying many diseases notably oral cancer, and has reconstructed the ancestries and relationships of ethnic populations groups of India and Asia using genomic methods and tools. He has immensely contributed to capacity-building in human and statistical genetics in India. He has published widely in journals of international renown. He has founded the National Institute of Biomedical Genomics, India. He is a Fellow of the Indian science academies and The World Academy of Sciences.
View DetailsApril 1, 2023 to till Present - Distinguished Professor, John C. Martin Centre for Liver Research & Innovations, Liver Foundation, West Bengal, India
July 1, 2020 to till Present - National Science Chair (Scientific Excellence) Science & Engineering Board, Government of India
November 1, 2016 to till September 30, 2022 - Distinguished Professor National Institute of Biomedical Genomics, Kalyani, India
September 1, 2018 to till Present - Emeritus Professor Indian Statistical Institute, Kolkata, India
July 22, 2022 to till Present - Honorary Professor Indian Institute of Science Education & Research, Kolkata, India
June 1, 2021 to till Present - Honorary Professor Indian Institute of Science Education & Research, Mohali, India
June 1, 2022 to till Present - Adjunct Professor Indraprastha Institute of Information Technology Delhi, New Delhi
March 4, 2010 to till September 30, 2016 - Director (Founding Director) National Institute of Biomedical Genomics, Kalyani, India
May 7, 2004 to till September 30, 2017 - Professor & Head (May 7, 2004-March 3, 2010), Human Genetics Unit Indian Statistical Institute, Kolkata, India
December 2009 to till December 2015 - Professor Indian Institute Science Education & Research, Kolkata, India
December 2007 to till November 2014 - Honorary Professor Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India
June 1, 1991 to till May 6, 2004 - Professor and Head (October 5, 1999 - May 6, 2004), Anthropology & Human Genetics Unit Indian Statistical Institute, Kolkata, India
2001 to till 2011 - Director (Hony. Founding Director) TCG-ISI Centre for Population Genomics, Kolkata, India
June 1, 1987 to till May 31, 1991 - Associate Professor Indian Statistical Institute, Kolkata, India
1990 to till 1996 - Genetics Consultant Center for Education & Drug Abuse Research, Western Psychiatric Institute & Clinic, University of Pittsburgh, USA
1987 to till 1989 - Visiting Assistant Professor of Human Genetics & Biostatistics University of Pittsburgh, USA
July 29, 1983 to till May 31, 1987 - Lecturer Indian Statistical Institute, Kolkata, India
1982 to till 1983 - Research Instructor Center for Demographic & Population Genetics, University of Texas, Houston, USA
1980 to till 1982 - Senior Research Associate Center for Demographic & Population Genetics, University of Texas, Houston, USA
Doctor of Philosophy (Statistics). 1982. Indian Statistical Institute, Calcutta, India.
Master of Statistics (Specialization: Applied Statistics & Data Analysis). 1975. Indian Statistical Institute, Calcutta, India.
Bachelor of Statistics (Honours). 1974. Indian Statistical Institute, Calcutta, India.
| 2023-: Member, Technical Advisory Group on Genomics, World Health Organisation (WHO) |
| 2023-: Member, Board of Governors, Assam down town University, Guwahati. |
| 2023-: Member, Executive Committee, Human Genome Organisation (HUGO) |
| 2023-: Member, Governing Board, Hyderabad Eye Research Foundation |
| 2022-: Member, Executive Committee, International Common Disease Alliance |
| 2019-2021: President, Indian Academy of Sciences |
| 2020-2022: Member, Organizing Committee, International Common Disease Alliance |
| 2020-: Member, Ethics Working Group, International Common Disease Alliance |
| 2017-: Vice-President, All India Congress of Cytology & Genetics |
| 2017-: Member, Organizing Committee, International Human Cell Atlas Project |
| 2019-: Co-chair, Equity Working Group, International Human Cell Atlas Project |
| 2019-: Member, Ethics Working Group, International Human Cell Atlas Project |
| 2017-2021: President, West Bengal Academy of Science & Technology. |
| 2016-2018: Council Member, Indian Academy of Sciences, Bangalore. |
| 2014-2015: Co-Chair, Regulatory and Ethics Working Group, Global Alliance for Global Health |
| 2026-2014: Council Member, Human Genome Organisation (HUGO); Re-elected on the Council for the period 2015-2017. |
| 2012-2013: Member, Global Agenda Council on Genetics, World Economic Forum |
| 2006-2008: Council Member (2006-2008), Indian National Science Academy |
| 2000-2002: Elected Member, Board of Directors, International Genetic Epidemiology Society |
| 2000-2002: Elected Chair, ELSI Committee, International Genetic Epidemiology Society |
| 1998-2006: Member, National Bioethics Committee (India) |
| 1993-1998: Elected Member of Executive Committee (1993 -1998), International Human Genome Diversity Project of the Human Genome Organisation (HUGO) |
| 1993-1996: Elected Member of Governing Council (1993 - 1996), Indian Society of Human Genetics |
| 1992-1994: Elected Member of Executive Committee (1992 - 1994), International Biometric Society (Indian Region) |
| Year | Award/Recognition |
|---|---|
| 2023 | Distinguished Lecture Fellowship, Indian National Science Academy |
| 2022 | Mahasamman (for excellence in scientific research and education), JIS Group. |
| 2022 | Best Scientist of the Year, 2021, Anandabazar Patrika Online (বছরের Best বিজ্ঞানী, 2021;) |
| 2021 | Jayanta Basu Memorial Award, Bangiya Bigyan Parishad, Kolkata, India (বিজ্ঞান গবেষণা, বিজ্ঞান প্রচার ও প্রসারে অবদানের জন্য বঙ্গীয় বিজ্ঞান পরিষদের 2021 সালের 'জয়ন্ত বসু স্মৃতি পুরস্কার') |
| 2021 | G.N. Ramachandran Gold Medal, Council of Scientific & Industrial Research, Delhi. |
| 2021 | Barclay Memorial Medal, 2020, of The Asiatic Society. |
| 2020 | National Science Chair (Scientific Excellence), SERB, Government of India. |
| 2020 | Sir Prafulla Chandra Ray Memorial Medal, University of Calcutta. |
| 2019 | D.Sc. (Honoris causa), Burdwan University, India. |
| 2018 | Golden Jubilee Commemoration Medal (Animal Sciences), 2018. Indian National Science Academy. |
| 2017 | Lifetime Achievement Award 2017, SciGenom Research Foundation, Bangalore |
| 2017 | Dr. Rustam D Ranji Rotary Award and Lecture, Rotary Club of Hyderabad Dist 3150, India. |
| 2016 | 2nd S.S. Agarwal Oration Award, Indian Society of Cancer Genetics. |
| 2015 | 5th G.K. Manna Memorial Lecture-Award, 17th All-India Congress of Cytology and Genetics, Indian Institute of Chemical Biology, Kolkata, 22 December 2015. |
| 2015 | Acharya Prafulla Chandra Ray Memorial Award, Institute of Pulmocare & Research, Kolkata, India. |
| 2015 | J.C. Bose National Fellowship, Govt. of India |
| 2014 | Lifetime Achievement Award, (India) Society of Biotechnologists’s M.V. Pylee Lifetime Achievement Award for Original Contributions to Biotechnology |
| 2014 | Centenary Medal for Excellence, School of Tropical Medicine, Kolkata, India |
| 2009 | TWAS Prize in Biology, The World Academy of Sciences, Trieste, Italy. |
| 2002 | G.D. Birla Award for Scientific Research, Shri K.K. Birla Foundation, New Delhi & Kolkata, India |
| 2001 | Shri Om Prakash Bhasin Award in Biotechnology, Shri Om Prakash Bhasin Foundation, New Delhi, India |
| 2000 | Ranbaxy Research Award in Applied Medical Sciences, Ranbaxy Science Foundation, New Delhi, India |
| 2000 | G.S. Randhawa Oration Award - 1999 of the Guru Nanak Dev University, Amritsar, India |
| 2000 | New Millennium Science Gold Medal, awarded by the Indian Science Congress Association and the Council of Scientific & Industrial Research (CSIR), Government of India. |
Founded and directed (2000-2010): TCG-ISI Centre for Population Genomics in Kolkata, India (a scientific research institution created by The Chatterjee Group, New York, USA, collaboratively with the Indian Statistical Institute, Kolkata.
Founded and directed (2010-2016): National Institute of Biomedical Genomics, Kolkata, India – a research and training institution created by the Government of India.
| 2021 | Member of the Advisory Board of Universal Scientific Education and Research Network (USERN) |
| 2015 | Re-Elected Member of Council, Human Genome Organisation (HUGO) |
| 2014 | Elected Member, International Statistical Institute, The Hague, The Netherlands |
| 2012 | Elected Member of Council, Human Genome Organisation (HUGO) |
| 2011 | Elected Member, TWAS: The Academy of Sciences for the Developing World, Trieste |
| 2010 | Elected Fellow, West Bengal Academy of Science & Technology |
| 2006 | Elected Fellow, The National Academy of Sciences, India |
| 2000 | Elected Fellow, Indian National Science Academy |
| 2000 | Elected Member, Human Genome Organization (HUGO) |
| 1998 | Elected Fellow, Indian Academy of Sciences |
| 2023: | Keynote Lecture, “Recent Advances in Biotechnology Enable Deeper Dissection of Human Disease,” International Symposium on Biotechnology, St. Xavier’s (Autonomous) College, October 12, 2023, Kolkata. |
| 2023: | Plenary Lecture, “Human Health: Essentiality of FAIRification of Health Data, with Special Reference to India,” International Conference on Open and FAIR Data Ecosystem: Principles, Policies, and Platforms. 11-13 September 2023, New Delhi. |
| 2023: | Plenary Lecture, “Celebrating Human Diversity to Attain ‘Peace, Justice and Strong Institutions’,” World Congress of Anthropology 2023, Bhubaneswar, 10 August 2023. |
| 2023: | Annual Oration, West Bengal Academy of Science & Technology, Kolkata, 4 July 2023. |
| 2023: | Convocation Address, 10th Convocation, Indian Institute of Science Education & Research, Kolkata, 27 June 2023. [Recording https://youtu.be/yUgPYvAhKgc, from 56.30 to 1:15.15] |
| 2023: | Nayudamma Memorial Lecture, Central Leather Research Institute, Chennai. 4 May 2023. [Recording https://www.youtube.com/watch?v=IplERSDuR04, from 18:30 to 1:09:20] |
| 2022: | Special Colloquium, Indian Institute of Science Education & Research, Kolkata. 16 November 2022. |
| 2022: | 3rd Foundation Day of the All-India Institute of Medical Science, Kalyani; Lecture as Chief Guest, 18 September 2022. |
| 2022: | Institute Colloquium, Indian Institute of Science Education & Research, Kolkata. 16 September 2022. |
| 2022: | Gregor Johann Mendel’s 200th Birth Anniversary Lecture, National Institute of Biomedical Genomics, Kolkata |
| 2022: | Dr. Lalji Singh Memorial Oration, National Institute of Animal Biotechnology, Hyderabad. [Recording https://www.youtube.com/watch?v=sqz9wfzLD5M, from 1:00:00 to 2:10:00] |
| 2022: | First Professor O.S. Reddi Memorial Oration, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad. |
| 2022: | Prasanta Chandra Mahalanobis Lecture on his 129th Birth Anniversary, Indian Statistical Institute, Kolkata |
| 2021: | Mrs. and Professor G.P. Talwar Oration, Association of Clinical Biochemists of India, December 14, 2021. |
| 2021: | Annual Day Oration of the National Institute of Malaria Research, New Delhi; November 8, 2021. |
| 2021: | 3rd M.K. Pal Memorial Lecture, Saha Institute of Nuclear Physics, Kolkata; March 20, 2021. |
| 2021: | 59th ICMR-NICED Foundation Day Oration, National Institute of Cholera & Enteric Diseases, February 18, 2021. |
| 2021: | 238th Foundation Day Lecture of The Asiatic Society, Kolkata. January 15, 2021. |
| 2021: | 10th Dr. V. Ramalingaswami Memorial Oration, Institute of Liver and Digestive Sciences, 8th August 2021. |
| 2020: | Henry Shaw Oration, Saroj Gupta Cancer Centre & Research Institute, Kolkata, 22nd February 2020. |
| 2018: | First Archana Sharma and Arun Kumar Sharma Memorial Oration, Archana Sharma Foundation, Kolkata |
| 2018: | Mahendra Lal Sircar Memorial Endowment Lecture, Indian Association for the Cultivation of Science, 14th December 2018. |
| 2018: | ‘Meet the Scientist’ Lecture, West Bengal State Student-Youth Science Fair, 30th January 2018, Netaji Indoor Stadium, Kolkata. |
| 2017: | Foundation Day Lecture of the Inter-University Centre for Astronomy and Astrophysics, 28th December 2017, Pune. [https://www.youtube.com/user/IUCAASciPOP/live] |
| 2017: | Rajasekhara Reddy Endowment Lecture of the Operational Research Society of India, 23rd December 2017, Kolkata. |
| 2017: | Presidency University Bicentenary Celebrations Lecture “The Walls of Classrooms are Developing Cracks: The Future Appears Bright.” 9th January 2017, Kolkata. [https://www.youtube.com/watch?v=eQ7SDbgnnBw] |
| 2016: | Air Vice Marshal V. Krishnaswamy Memorial Oration, Madhuram Narayanan Centre for Exceptional Children, Chennai, 17th November 2016. |
| 2016: | Sudhindranath Mukherjee Memorial Oration, Indian Association of Cancer Research, 16 June 2016. |
| 2016: | B. Ramamurthy Memorial Lecture, National Brain Research Centre, Manesar, 29 January 2016. |
| 2015: | D.M. Bose Memorial Lecture, Bose Institute, Kolkata, 26 November 2015. |
| 2015: | Igniting Innovations in Young Minds Lecture, Pulmocon-2015, Institute of Pulmocare & Research, Kolkata, 10 October 2015. |
| 2014: | Foundation Day Lecture, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 18 November 2014 |
| 2014: | Public Lecture, Indian Institute of Science Education & Research, Mohali, 29 October 2014 |
| 2014: | Centenary Lecture, School of Tropical Medicine, 27 March 2014 |
| 2013: | Golden Jubilee Lecture, Pandit Ravishankar Shukla University, Raipur, 27 December 2013. |
| 2013: | First D.K. Sen Memorial Lecture, Indian Anthropological Society, Kolkata, September 13, 2013. |
| 2013: | 20th Foundation Day Oration, Society for Advancement of Human Development & Research, Kolkata, July 21, 2013, |
| 2013: | First Aloke K. Ghosh Memorial Lecture, Department of Anthropology, University of Calcutta, June 5, 2013. |
| 2013: | B. Mukherji Oration, Indian Pharmacological Society, Kolkata, February 23, 2013 |
| 2013: | Third Dr. Basu Kumar Bagchi Memorial Lecture, Geeta Palace, Shantipur, West Bengal, January 14, 2013. |
| 2012: | Golden Jubilee Lecture of the Indian International Centre, New Delhi. December 1, 2012. [http://www.iicdelhi.in/webcasts/play_webcast/unity-and-diversity-of-india---a-genomic-reconstruction-from-ancestral-footfalls/] |
| 2012: | B.N. Chopra Memorial Lecture, School of Tropical Medicine, Kolkata, February 24, 2012. |
| 2011: | First Foundation Day Plenary Lecture, Centre for Cellular and Molecular Platforms, Bangalore, November 18, 2011 |
| 2011: | Prasanta Chandra Mahalanobis Memorial Lecture, Department of Science & Technology, Government of West Bengal, February 28, 2011 |
| 2011: | J.C. Ray Oration, Indian Institute of Chemical Biology, April 2, 2011. |
| 2011: | L.D. Sanghvi Oration Award, Indian Society of Human Genetics, February 16, 2011. |
| 2010: | West Bengal Academy of Science & Technology Annual Oration, December 27, 2010 |
| 2010: | Professor S.K. Bhattachaya Oration Award, Indian Society of Medical Statistics, November 2010. |
| 2010: | Golden Jubilee Lectures, Indian Institute of Technology, Kanpur, 12-13 April 2010 |
| 2009: | Professor S.P. Ray-Chaudhuri Memorial Lecture, S.P. Ray-Chaudhuri Foundation, Benaras Hindu University, 2 March 2009. |
| 2008: | Dr. Gour Gopal Das Memorial Oration of the Indian Physical Society, 28 March 2008, Bose Institute, Kolkata. |
| 2008: | India Foundation Day Lecture, 20 February 2008, “The Indian Identity in Science”, Kolkata. |
| 2008: | Foundation Day Oration, 11 February 2008, Institute of Life Sciences, Bhubaneswar. |
| 2007: | V. Ramalingaswami Memorial Lecture, 30 July 2007, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore. |
| 2006: | The 3rd Jyotirmoy Das Memorial Lecture, 2006, XXIX All India Cell Biology Conference, Lucknow. |
| 2006: | National Science Day Lecture, 28 February 2006, National Chemical Laboratory (CSIR), Pune. |
| 2005: | The 8th Manasi Ram Memorial Lecture, 23 November 2005, Miranda House, University of Delhi. |
| 2005: | The 2nd C.C. Li Memorial Lecture of the University of Pittsburgh, entitled “Our Footprints in the Sands of Time: A Statistical-Genetic Traceback”, 29 April 2005, Pittsburgh, U.S.A. |
| 2004: | Dimensions of Science Lecture entitled “Tribes, Castes and Genes”, India International Centre, New Delhi, 16 July 2004. |
| 2004: | Shri J.N. Bose Memorial Oration entitled “Genetics and the Practice of Medicine – Great Expectations”, R.G. Kar Medical College & Hospital’s Foundation Day, 5 July 2004, Kolkata. |
| 2003: | Institute Lecture – 2003, Indian Institute of Technology, Kanpur. |
| 2003: | UNESCO Lecture in celebration of the 10th Anniversary of the IBC and the 50th Anniversary of the Discovery of DNA Structure entitled “Our Place in the Genomic Universe”, 14 May 2003, Paris. |
| 2003: | Bireswar Chakraborty Memorial Oration – 2003, L.V. Prasad Eye Institute, Hyderabad |
| 2001: | CSIR Foundation Day Lecture - 2001, Institute of Microbial Technology, Chandigarh. |
| 2001: | U.S. National Institutes of Health “Stigma & Global Health” Lecture, 6 September 2001, Washington D.C. |
| 2001: | NCBS-CSCS ‘Through the Lens of Life Sciences’ Public Lecture entitled 'Human Footprints in the Sands of Time: A Genetic Reconstruction with Special Reference to India'. Bangalore, 20 April 2001 |
| 2000: | Foundation Day Lecture - 2000, National Institute of Immunology, New Delhi. |
| 2000: | Foundation Day Lecture - 2000, Centre for Archaeological Studies & Training (Eastern India), Calcutta. |
| 2000: | Platinum Jubilee Lecture, Anthropology & Archaeology Section, Indian Science Congress, 2000, Pune, entitled Anthropology and Genomics: The Landscape of this Interface. |
| 2000: | Special Lecture, Sixty-sixth mid-year Meeting of the Indian Academy of Sciences, Bangalore |
| 1999: | Lt. Col. Upendranath Mukerjee Oration 1999 of the Federation Hall Society, Calcutta, entitled Human Genome Studies: Some Ethical Issues and Dilemmas. |
| 1998: | Platinum Jubilee Lecture, Statistics Section, Indian Science Congress, 1998, Hyderabad, entitled Some Statistical Methods and Applications in Human Genetics. |
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Fireside Chat https://informationmatters.org/2022/11/deciphering-the-genetic-heritage-of-the-people-of-india-fireside-chat-with-partha-majumder/ |
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A narrative and contextualization of the work of Svante Pääbo, Nobel prize awardee 2022 in physiology or Medicine, 2022 https://www.youtube.com/watch?v=yQBbHAmrTo0 |
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Mendel’s 200th Birth Centenary Lecture (“Mendel: A Man of God and a Paragon of Science”) https://www.youtube.com/watch?v=-tcQ-TPa148 |
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Bose Colloquium on Genes as a Guide to Human History and Culture https://www.youtube.com/watch?v=mtb64ZuSxr8 |
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Lalji Singh Memorial Lecture https://www.youtube.com/watch?v=sqz9wfzLD5M |
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Science Frontiers discussion with Dr. Binay Panda https://youtu.be/7w8Bg048sWk |
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Talk on P.C. Mahalanobis in the S.N. Bose National Centre for Basic Sciences, Kolkata https://www.youtube.com/watch?v=Z--NOujz-Z4 |
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Genomic Drivers of Oral Cancer & Proximal Metastasis https://www.youtube.com/watch?v=p0v8K_oCQLA |
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Interview by Dr. Abhijit Chowdhury for Bigyanbhash (in Bengali) Part-1: https://www.youtube.com/watch?v=_zg3o8GWNoQ Part-2: https://www.youtube.com/watch?v=8B6OiWNBYNA |
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“Celebrating Human Diversity in India,” National Science Day Lecture, Indian Institute of Technology, Jodhpur, 2022 https://www.youtube.com/watch?v=qyVvhHA4t9o |
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“Genes as a Guide to Human History and Culture,” 10 November 2021 https://www.youtube.com/watch?v=mtb64ZuSxr8 |
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“… and as we moved, we embraced and we absorbed,” Indian Institute of Science Education & Research, 21 November 2022 https://www.youtube.com/watch?app=desktop&v=yQBbHAmrTo0 |
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“Evolution and Spread of the Novel Coronavirus,” Jawahar Navodaya Vidyalaya, Bengaluru https://www.youtube.com/watch?v=T-rjxxB_mqw |
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As the President of the West Bengal Academy of Science & Technology, Partha Majumder delivered many talks and gave many interviews on the SARS-CoV-2 and COVID-19. These are compiled on: https://www.wast.in/fellows-COVID-19.html |
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“A bouquet of stories,” Adamas University, October 18, 2019 https://biotechnology.adamasuniversity.ac.in/colloqium-a-bouquet-of-stories/ |
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Interview: ET Health World https://www.youtube.com/watch?v=d5OErxtJsk0 |
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Mahalanobis, anthropometric diversity and the birth of human genetics in India https://youtu.be/M7-qMGgx86I Lecture in Symposium on Prasanta Chandra Mahalanobis: A tribute to his scientific contributions 30th Mid Year Meeting of the Indian Academy of Sciences 28-29 June 2019 Indian Institute of Science, Bengaluru |
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On June 24, 2017, Professor Partha Majumder participated in a hour-long discussion on “The Kith and Kin” (#TKAK) with Professor Raghavendra Gadagkar of IISc and Professor Deepak Mehta of Shiv Nader University. The discussion is available for free-listening on • https://syntalk.wordpress.com/episodes/turn-three/tkak/ (website link) • https://goo.gl/BkxaBH (short link, SoundCloud). |
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Genes and Probabilities: https://www.youtube.com/watch?v=oiDbzevzQdE |
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Infectious Disease – Tuberculosis: https://www.youtube.com/watch?v=2mxkGDMgZzM |
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Eureka: https://www.youtube.com/watch?v=2mxkGDMgZzM |
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An Overview of Our Second Genome: https://www.youtube.com/watch?v=jN5IPBB5P6o |
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Mint Interview: https://www.youtube.com/watch?v=s-s5pTNbWLE |
Genome Biology and Evolution (2014-2017)
Human Genetics (2013-2015)
BMC Genetics (2012)
Journal of Biosciences (2012)
Annals of Human Genetics [London] (2008-2013)
Genome Research [Cold Spring Harbor Laboratory,USA] (2008-2012)
Sankhya - The Indian Journal of Statistics [Calcutta] (2000-2002)
Genetic Epidemiology [International Genetic Epidemiology Society, USA] (1997-2001)
Human Biology [USA] (1995 - 1997)
Journal of Human Ecology [India] (1994 - 2004)
Indian Journal of Human Genetics [Indian Society of Human Genetics] (1995 - 2015)
Journal of Genetics (1996)
Annals of Human Biology [U.K.] (2001-2007)
Anthropological Science [Japan] (2000)
Journal of Biosciences [Indian Academy of Sciences] (2006)
Resonance [Indian Academy of Sciences] (1995 -1996)
Rendered service to the Office of the Principal Scientific Adviser to the Government of India, Indian National Science Academy, various agencies of the Government of India, particularly Department of Biotechnology, Department of Science & Technology, Indian Council of Medical Research, Indian Council of Agricultural Research and Council of Scientific & Industrial Research and to various Universities and Institutes, as member of Task Forces, Monitoring Committees and Review Boards, Scientific Advisory Committes, and Committees for the promotion of international co-operation in science.
Currently serving: Member of Organizing Committee of International Common Disease Alliance, Executing Committee of the (international) Human Cell Atlas, Co-Chair of the Equity Working group of the Human Cell Atlas, Ethics Working Group of the Human Cell Atlas
2019-2021: Co-Chair, Expert Group for World Health Organization Guidance on “Ethics and Governance of Artificial Intelligence on Health,” 2019. The report on Ethics and Governance of Artificial Intelligence in Health: WHO Guidance has been published by the WHO on June 28, 2021 (https://www.who.int/publications/i/item/9789240029200).
2002-2003: UNESCO: Served as a Genomics Expert on the Drafting Group of the International Declaration on Human Genetic Data.
2000-2001: International Genetic Epidemiology Society: Chaired an Expert Group to resolve an international public debate on ethics and human rights arising from the use of measles vaccine among the Yanomama tribals of Brazil.
1999: Served as an Expert Commentator to the British Parliament on organization of genomics activities in the U.K., 1999
Founding Member, International Genetic Epidemiology Society
Life Member, Asia-Pacific Society of Human Genetics
Life Member, Indian Society of Human Genetics
Life Member, Indian Society of Medical Statistics
Life Member, Indian Anthropological Society
Life Member, Association for the Promotion of DNA Fingerprinting & Other Technologies
Member, American Society of Human Genetics
Member, International Biometrics Society
(Honorary) Life Member, Society for Biotechnologists (India)
Abhijit Chowdhury is a clinician scientist with Nonalcoholic fatty liver diseases (NAFLD) as his research focus. His major contribution had been in bringing the phenotype lean NAFLD, initially considered as an outlier, to global research focus and discourses. He has been associated with development of the Birbhum population project – a health and demographic surveillance system- as a population laboratory for analytical and interventional research in public health and demography. He is Professor of Hepatology at IILDS and is fellow of Indian National Science Academy (INSA) as well as National Academy of Sciences in India (NASI).
View DetailsEMPLOYMENT / APPOINMENT
| Indian Institute of Liver and Digestive Sciences (IILDS) Professor and Clinical Director - Hepatology |
West Bengal, India 2016 – till date |
| John C Martin Centre for Liver Research and Innovations Department of Disease Biology and Research Integration, IILDS Associate Director and Lead |
West Bengal, India 2021 – till date |
| Society for Health and Demographic Surveillance Project Director |
West Bengal, India 2008 – till date |
| Institute of Post Graduate Medical Education and Research West Bengal Medical Education Service Assistant Professor/ Associate Professor / Professor |
West Bengal, India 1998 - till date |
| Chief, COVID-19 Task Force Government of West Bengal |
West Bengal, India 2020 |
| Convenor, Global Advisory Board COVID-19 Containment in West Bengal Government of West Bengal |
West Bengal, India 2020 |
EMPLOYMENT / APPOINMENT
| Postgraduate Institute of Medical Education and Research DM (Gastroenterology) MD |
Chandigarh, India 1993 1987 |
| North Bengal University MBBS |
West Bengal, India 1983 |
EMPLOYMENT / APPOINMENT
Non-Alcoholic Fatty Liver Disease (NAFLD)
Epidemiology and Burden of Liver Diseases
Non-Communicable Diseases (NCDs)
Population Impact of Rural Healthcare Delivery Models
FELLOWSHIP/ AWARD
| Distinguished Visiting Fellow, Harvard T H Chan School of Public Health, USA | 2015 |
| Fellow, Indian National Science Academy (FNA) | 2012 |
| Fellow, National Academy of Sciences (FNASc) | 2009 |
RESEARCH PROJECT AND FUNDING
| International | |
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Project: Development of research infrastructure Funding Agency: John C Martin Foundation, USA Duration: 2022-2027 Role: Principal Investigator Cost: USD ($) 7.8 million |
Project: Development of Care facility for IILDS, Sonarpur, Kolkata Funding Agency: John C Martin Foundation, USA Duration: 2018-2019 Role: Principal Investigator Cost: USD ($) 2 million |
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Project: Infrastructural grant, IILDS, Sonarpur, Kolkata Funding Agency: Gilead Foundation, USA Duration: 2016 Role: Principal Investigator Cost: USD ($) 2 million |
Project: Development of a Care model for HBV IN Arunachal Pradesh Funding Agency: John C Martin Foundation, USA Duration: 2012-2016 Role: Principal Investigator Cost: USD ($) 1.2 million |
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Project: Centre for Excellence in rural health care Funding Agency: Bristol Myers’ Squibb Foundation, USA Duration: 2011-2015 Role: Principal Investigator Cost: USD ($) 760, 000 |
Project: HCV – the Indian Face and Action Funding Agency: Bristol Myers’ Squibb Foundation, USA Duration: 2009-2012 Role: Principal Investigator Cost: USD ($) 222, 000 |
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Project: Science to Society Funding Agency: Bristol Myers’ Squibb Foundation, USA Duration: 2007-2010 Role: Principal Investigator Cost: USD ($) 170, 000 |
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| National | |
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Project Title: To identify and validate functionally, variants in immune genes as predictor and microRNA restricting those genes as therapeutic for alcohol induced liver diseases: an in vitro and in vivo study. Funding Agency: Department of Biotechnology, Government of India Duration: 2018-2021 Role: Principal Investigator Cost: INR₹ 50 Lakhs |
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Project Title: Assessment of the burden of Metabolic Syndrome linked Diseases in the General population: Organization of a cohort for future studies. Funding Agency: Department of Science & Technology, Government of West Bengal Duration: 2015-2018 Role: Principal Investigator Cost: INR₹ 30 Lakhs |
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Project Title: Biology of Hepatitis B virus of genotype D in an integrated clinic-virological Perspective Funding Agency: Department of Biotechnology, Government of India. Duration: 2013-2016 Role: Principal Investigator Cost: INR₹ 35 Lakhs |
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Project Title: Genomic and Epigenomic analyses of non-alcoholic fatty liver disease (NAFLD) in the Indian population. Funding Agency: Department of Biotechnology, Government of India Duration: 2013-2016 Role: Principal Investigator Cost: INR₹ 219 Lakhs |
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Project Title: Differential expression of NADPH oxidase in activation, senescence and apoptosis of hepatic stellate cells during hepatic fibrosis in mice. Funding Agency: Indian Council of Medical Research Duration: 2012-2015 Role: Principal Investigator Cost: INR₹ 42 Lakhs |
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Project Title: Hepatic Stellate Cells (HSCs) activation during Isoniazid induced hepatocytes injury: An in-vitro study. Funding Agency: Indian Council of Medical Research Duration: 2011-2014 Role: Principal Investigator Cost: INR₹ 92 Lakhs |
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Project Title: Study of Hepatitis B virus (HBV) resistance patterns in patients with chronic infection during therapy with nucleoside and nucleotide analogues. Funding Agency: Indian Council of Medical Research Duration: 2009-2011 Role: Principal Investigator Cost: INR₹ 32 Lakhs |
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Project Title: Multicentric study of Interferon – Glycyrrhizin combination therapy and Interferon - Ribavirin combination therapy in the management of Chronic Hepatitis – C. Funding Agency: Indian Council of Medical Research Duration: 2008-2012 Role: Principal Investigator Cost: INR₹ 25 Lakhs |
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Project Title: Insight into pathogenetic mechanisms in Anti-Tuberculosis Drugs (ATD) induced Hepatotoxicity. Funding Agency: Indian Council of Medical Research Duration: 2007-2010 Role: Principal Investigator Cost: INR₹ 26 Lakhs |
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Project Title: Epidemiology of Viral Hepatitis in Tribal population. Funding Agency: Indian Council of Medical Research Duration: 2006-2009 Role: Principal Investigator Cost: INR₹ 10 Lakhs |
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Project Title: Studies on the Spectrum and Mechanism of Liver Disease in Chronic Arsenic Toxicity. Funding Agency: Indian Council of Medical Research Duration: 2006-2008 Role: Principal Investigator Cost: INR₹ 42 Lakhs |
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SELECT PUBLICATION
| td>A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023 Jun 24. doi: 10.1097/HEP.0000000000000520. |
| Stepwise evaluation for the risk of metabolic unhealthiness and significant non-alcoholic fatty liver disease in India. Lancet Reg Health Southeast Asia. 2023; 12:100142. |
| Diverse facets of MDSC in different phases of chronic HBV infection: Impact on HBV-specific T-cell response and homing. Hepatology. 2022; 76(3): 759-774. |
| Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors. J Virol. 2022; 96(2): e0180021. |
| Clinical Profile of Hepatoblastoma: Experience From a Tertiary Care Centre in a Resource-Limited Setting. Cureus. 2022; 14(7): e26494. |
| Epidemiology of Liver Diseases in India. Clin Liver Dis (Hoboken). 2022; 19(3): 114-117. |
| Prevalence and health status of COPD in rural West Bengal. Lung India. 2022; 39(3): 242-246. |
| A Model of Care Optimized for Marginalized Remote Population Unravels Migration Pattern in India. Hepatology. 2021; 73(4): 1261-1274. |
| rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis. J Hepatol. 2021; 74(1): 20-30. |
| Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians. Gene. 2021; 775: 145431. |
| Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis. PLoS One. 2021; 16(8): e0255915. |
| Messages on COVID-19 Prevention in India Increased Symptoms Reporting and Adherence to Preventive Behaviors Among 25 Million Recipients with Similar Effects on Non-recipient Members of Their Communities. NBER Working Paper, w27496. July 2020. |
| Non-communicable diseases are the leading cause of mortality in rural Birbhum, West Bengal, India: a sex-stratified analysis of verbal autopsies from a prospective cohort, 2012-2017. BMJ Open. 2020; 10(10): e036578. |
| A novel microRNA boosts hyper-β-oxidation of fatty acids in liver by impeding CEP350-mediated sequestration of PPARα and thus restricts chronic hepatitis C. RNA Biol. 2020: 1-12. |
| The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein. Int J Cancer. 2020; 147(10): 2934-2947. |
| Incidence of Prehypertension and Hypertension in Rural India, 2012-2018: A Sex-Stratified Population-Based Prospective Cohort Study. Am J Hypertens. 2020; 33(6): 552-562. |
| The transcontinental variability of nonalcoholic fatty liver disease . Hepatoma Res 2020;6:72. |
| Singal Prevalence and Profile of Nonalcoholic Fatty Liver Disease in Lean Adults: Systematic Review and Meta-Analysis . Hepatology Communications 2020; 4 ; 953-972. |
| Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis. J Clin Exp Hepatol. 2020; 10(4): 339-376. |
| Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism. Int J Hepatol. 2020; 2020: 6987295. |
| Epidemiology of non-alcoholic and alcoholic fatty liver diseases. Transl Gastroenterol Hepatol. 2020; 5: 16. |
| Double burden of malnutrition among adolescents in rural West Bengal, India. Nutrition. 2020; 79-80: 110809. |
| Sociodemographic Determinants of Preterm Birth and Small for Gestational Age in Rural West Bengal, India. J Trop Pediatr. 2019; 65(6): 537-546. |
| Non-alcoholic fatty liver disease in lean individuals. JHEP Rep. 2019; 1(4): 329-341. |
| CD8+CD28- T cells: key cytotoxic players impacting disease pathogenesis in chronic HBV infection. Clin Sci (Lond). 2019; 133(17): 1917-1934. |
| Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Version 2. Hepatol Int. 2019; 13(4): 353-390. |
| Myeloid-derived suppressor cells induce regulatory T cells in chronically HBV infected patients with high levels of hepatitis B surface antigen and persist after antiviral therapy. Aliment Pharmacol Ther. 2019; 49(10): 1346-1359. |
| Sofosbuvir-velpatasvir single-tablet regimen administered for 12 weeks in a phase 3 study with minimal monitoring in India. Hepatol Int. 2019; 13(2): 173-179. |
| Sociodemographic Determinants of Preterm Birth and Small for Gestational Age in Rural West Bengal, India. J Trop Pediatr. 2019; 65(6): 537-546. |
| Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals. Clin Gastroenterol Hepatol. 2019; 17(1): 54-64.e1. |
| Prospective cohort study of overweight and obesity among rural Indian adults: sociodemographic predictors of prevalence, incidence and remission. BMJ Open. 2018; 8(8): e021363. |
| Distinctiveness in virological features and pathogenic potentials of subgenotypes D1, D2, D3 and D5 of Hepatitis B virus. Sci Rep. 2018; 8(1): 8055. |
| The burden of iron-deficiency anaemia among women in India: how have iron and folic acid interventions fared? WHO South East Asia J Public Health. 2018; 7(1): 18-23. |
| Antimicrobial activity of ellagic acid against Helicobacter pylori isolates from India and during infections in mice. J Antimicrob Chemother. 2018; 73(6): 1595-1603. |
| Metabolic syndrome among rural Indian adults. Clin Nutr ESPEN. 2018; 23: 129-135. |
| Oncogenic potential of hepatitis B virus subgenotype D1 surpasses D3: significance in the development of hepatocellular carcinoma. Carcinogenesis. 2018; 39(2): 283-292. |
| Underweight among rural Indian adults: burden, and predictors of incidence and recovery. Public Health Nutr. 2018; 21(4): 669-678. |
| Effects of atorvastatin on portal hemodynamics and clinical outcomes in patients with cirrhosis with portal hypertension: a proof-of-concept study. Eur J Gastroenterol Hepatol. 2018; 30(1): 54-59. |
| Preference in place of delivery among rural Indian women. PLoS One. 2017; 12(12): e0190117. |
| Etiology and mode of presentation of chronic liver diseases in India: A multi centric study. PLoS One. 2017; 12(10): e0187033. |
| Probable psychiatric disorder in a rural community of West Bengal, India. Soc Psychiatry Psychiatr Epidemiol. 2017; 52(12): 1495-1500. |
| Synergistic impact of mutations in Hepatitis B Virus genome contribute to its occult phenotype in chronic Hepatitis C Virus carriers. Sci Rep. 2017; 7(1): 9653. |
| MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2. Cell Death Dis. 2017; 8(3): e2706. |
| HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy. Sci Rep. 2017; 7: 44742. |
| Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Cell Host Microbe. 2017; 21(3): 376-389. |
| Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet Gastroenterol Hepatol. 2016; 1(3): 185-195. |
| Natural killer cells contribute to hepatic injury and help in viral persistence during progression of hepatitis B e-antigen-negative chronic hepatitis B virus infection. Clin Microbiol Infect. 2016; 22(8): 733.e9-733.e19. |
| The impact of training informal health care providers in India: A randomized controlled trial. Science. 2016; 354(6308). pii: aaf7384. |
| Socio-economic disparities in tobacco consumption in rural India: evidence from a health and demographic surveillance system. Perspect Public Health. 2016; 136(5): 278-287. |
| Alcohol Use-Related Problems Among a Rural Indian Population of West Bengal: An Application of the Alcohol Use Disorders Identification Test (AUDIT). Alcohol Alcohol. 2016; 51(2): 215-223. |
| Tobacco use and self-reported morbidity among rural Indian adults. Prim Health Care Res Dev. 2016; 17(5): 514-523. |
| Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India. PLoS One. 2016; 11(3): e0149843. |
| Hepatic miR-126 is a potential plasma biomarker for detection of hepatitis B virus infected hepatocellular carcinoma. Int J Cancer. 2016; 138(11): 2732-2744. |
| Hepatitis B Virus X Protein Upregulates hELG1/ ATAD5 Expression through E2F1 in Hepatocellular Carcinoma. Int J Biol Sci. 2016; 12(1): 30-41. |
| Correlates of disease-specific knowledge among patients with chronic hepatitis B or hepatitis C infection in India. Hepatol Int. 2016; 10(6): 988-995. |
| Hepatic steatosis is associated with cardiometabolic risk in a rural Indian population: A prospective cohort study. Int J Cardiol. 2016; 225: 161-166. |
| Physiological and behavioral risk factors of type 2 diabetes mellitus in rural India. BMJ Open Diabetes Res Care. 2016; 4(1): e000255. |
| Health & Demographic Surveillance System Profile: The Birbhum population project (Birbhum HDSS). Int J Epidemiol. 2015; 44(1): 98-107. |
| Comparative analyses of genetic risk prediction methods reveal extreme diversity of genetic predisposition to nonalcoholic fatty liver disease (NAFLD) among ethnic populations of India. J Genet. 2015; 94(1): 105-13. |
| Immune-driven adaptation of hepatitis B virus genotype D involves preferential alteration in B-cell epitopes and replicative attenuation--an insight from human immunodeficiency virus/hepatitis B virus coinfection. Clin Microbiol Infect. 2015; 21(7): 710.e11-20. |
| Gut microbiomes of Indian children of varying nutritional status. PLoS One. 2014; 9(4): e95547. |
| Distinct distribution pattern of hepatitis B virus genotype C and D in liver tissue and serum of dual genotype infected liver cirrhosis and hepatocellular carcinoma patients. PLoS One. 2014; 9(7): e102573. |
| Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma. PLoS One. 2014; 9(10): e110012. |
| New HBV subgenotype D9, a novel D/C recombinant, identified in patients with chronic HBeAg-negative infection in Eastern India. J Viral Hepat. 2013; 20(3): 209-218. |
| Lean NASH: distinctiveness and clinical implication. Hepatol Int. 2013; 7 Suppl 2: 806-813. |
| Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population. Gene. 2012; 509(1): 178-88. |
| Tracking the naturally occurring mutations across the full-length genome of hepatitis B virus of genotype D in different phases of chronic e-antigen-negative infection. Clin Microbiol Infect. 2012; 18(10): E412-418. |
| Normal’ liver stiffness measure (LSM) values are higher in both lean and obese individuals: a population-based study from a developing country. Hepatology 2012; 55: 584-593. |
| A Genome-Wide Search for Non-UGT1A1 Markers Associated with Unconjugated Bilirubin Level Reveals Significant Association with a Polymorphic Marker Near a Gene of the Nucleoporin Family. Ann Hum Genet. 2012; 76: 33–41. |
| Significant association of the dupA gene of Helicobacter pylori with duodenal ulcer development in a South-east Indian population. J Med Microbiol. 2012; 61(Pt 9): 1295-302. |
| Distinct repeat motifs at the C-terminal region of CagA of Helicobacter pylori strains isolated from diseased patients and asymptomatic individuals in West Bengal, India. Gut Pathog. 2012; 4(1): 4. |
| Multiple infection and microdiversity among Helicobacter pylori isolates in a single host in India. PLoS One. 2012; 7(8): e43370. |
| Intact cag pathogenicity island of Helicobacter pylori without disease association in Kolkata, India. Int J Med Microbiol. 2011; 301(4): 293-302. |
| IL1B induced Smad 7 negatively regulates gastrin expression. PLoS One. 2011; 6(3): e14775. |
| Obscure GI bleeding in the tropics: impact of introduction of double-balloon and capsule endoscopies on outcome. Gastrointest Endosc. 2010; 72: 292-300. |
| Course of disease and survival after onset of decompensation in Hepatitis B Virus (HBV) related cirrhosis. Liver Int 2010; 30: 1033–1042. |
| Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology. 2010; 51: 1593 – 1602. |
| Unique hepatitis B virus subgenotype in a primitive tribal community in eastern India. J Clin Microbiol. 2010; 48: 4063-4071. |
| Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice. Toxicol Appl Pharmacol. 2010; 251: 59-69. |
| Indistinguishable cellular changes in gastric mucosa between Helicobacter pylori infected asymptomatic tribal and duodenal ulcer patients. World J Gastroenterol. 2009; 15: 1105-1112. |
| promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int J Biochem Cell Biol. 2009; 41: 1502-1510. |
| Irritable bowel syndrome: an international study of symptoms in eight countries. Eur J Gastroenterol Hepatol. 2008; 20:659-667. |
| Alterations in natural killer cells and natural killer T cells during acute viral hepatitis E. J Viral Hepat. 2008; 15: 910-916. |
| Arsenic induces apoptosis in mouse lier is mitochondria dependent and is abrogated by N-acetylcysteine. Toxicol Appl Pharmacol. 2007; 220: 146 – 155. |
| Gilbert’s syndrome: High frequency of the (TA) TAA Allele in India and its interaction with a novel CAT insertion in the promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 (UGT1A1). World J Gastroenterol. 2006; 12: 2269– 2275. |
| Mitochondrial oxidative stress and permeability transition in Isoniazid and Rifampicin induced liver injury in mice J Hepatol. 2006; 45: 117–126. |
| Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer. Hum Mutat. 2006; 27: 411- 419. |
| Immune response to an indigenously developed r-Hepatitis B vaccine in mixed population: Study of an accelerated vaccination schedule. World J Gastroenterol. 2005; 11:1037-39. |
| Diagnosis and Genotyping of Helicobacter pylori by Polymerase Chain Reaction of Bacterial DNA from Gastric juice. J Gastroenterol Hepatol. 2005; 20:1253-1259. |
| Community based epidemiology of Hepatitis B virus Infection in West Bengal, India: Prevalence of HBeAg negative infection and associated viral variants. J Gastroenterol Hepatol. 2005; 20: 1712–1720. |
| Molecular epidemiology of HCV infection among acute and chronic liver disease patients in Kolkata, India. J Clin Virol. 2005; 32:38-46. |
| Hepatitis B infection in Eastern Indian families: need for screening of adult siblings and mothers of adult index cases. Public Health. 2005; 119:647-654. |
| Most Helicobacter pylori strains of Kolkata in India are resistance to metronidazole but susceptible to other drugs commonly used for eradication and ulcer therapy. Aliment Pharmacol Ther. 2005; 22: 51-57. |
| Nucleic acid sequence analysis of basal core promoter/precore/core region of hepatitis B virus isolated from chronic carriers of the virus from Kolkata, eastern India: low frequency of mutation in the precore region. Intervirology. 2005; 48: 389 -399. |
| Multiplex PCR assay for rapid detection and genotyping of Helicobacter pylori directly from the biopsy specimens. J Clin Microbiol. 2004; 42: 2821–2824. |
| Ethnic differences in allele distribution for the IL8 and IL1B genes in populations from eastern India. Hum Biol. 2004; 76: 153–159. |
| Anti-Helicobacter pylori therapy in India: differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene. J Gastroenterol Hepatol. 2003; 18: 190–195. |
| Hepatitis C virus infection in general population: A rural community based study in West Bengal, India. Hepatology. 2003; 37: 802–809. |
| Virulence genes and natural DNA markers of Helicobacter pylori isolated from different ethnic communities of West Bengal, India. J Clin Microbiol. 2003; 41: 3737–3743. |
EDITORIAL BOARD MEMBER
Hepatology International
BMJ
Immunology, DST Inspire Faculty
View Details2023 - Guest Editor for JoVE,
2023 - Early Career Editor Gene Expression
2022 - Alimentary Pharmacology & Therapy
2020 - Clinical Gastroenterology and Hepatology
2018 - Ad hoc reviewer of Journal of Virology
2019 - Ad hoc reviewer of Journal for laboratory Physician
2015 - Reviewer of Scandinavian Journal of Immunology
2018 - Reviewer Plos One
2015 - Reviewer Virology
I have a keen interest in Viral Immunology, specifically in the area of mother-to-baby vertical transmission of HBV and HEV. Since 2011, I have been researching the mechanism of HBsAg seroconversion in chronic HBV patients.
The current focus of our lab is studying the immune responses and mechanisms involved in viral hepatitis infections, with a particular emphasis on Hepatitis B. We aim to identify the nature of vertical transmission from mother to baby, investigate the mechanisms of seroconversion of Hepatitis B surface antigen, and redefine the nature of immune responses and mechanism of Hepatitis B-mediated immune pathogenesis.
In addition, our lab is focused on developing novel biomarkers for the early diagnosis and prevention of hepatitis B-mediated advanced liver diseases. We are also developing high-throughput omics facilities such as single-cell sequencing, transcriptomics, proteomics, genomics, and metabolomics to gain insights and develop novel biomarkers and therapeutics for liver diseases.
Overall, the Viral Hepatitis and Immunology Lab's focus is to improve our understanding of the immune response to viral hepatitis infections and develop effective diagnostic and therapeutic strategies to combat these diseases."
Dr. Amal Kumar Santra is the Director of John C Martin Centre for Liver Research & Innovation.
John C Martin Centre for Liver Research and innovations is envisioned as a research Institute doing basic and translational research in Liver diseases and Medicine. The ever vibrant Spirit and creative visions of the legendary scientist, innovators and humanist John C Martin remain our inspiration. JCMLRI wish to inculcate a culture and practice of answering research questions that have contextual relevance for the developing nations. As our new building is coming up in the IILDS campus at Sonarpur, we are forging collaborations with institutes in India and overseas for exchange and acceleration of ideas, capacities and outcomes. The Memorandum of understanding that Liver Foundation, West Bengal recently has developed with Virginia Commonwealth University, Richmond, USA is an excellent beginning. We plan to undertake training programs in Liver Diseases and allied areas for the scientists of north eastern states. We aim at fostering an ambience of liver research overall. Undertaking clinical research programs as well as implementation research in the broad public health domain is also in our agenda. Despite being focused in Liver disease, we encourage and engage in medical research in broader domain if that transects the institutes priorities.
I do hope that our faculty, with a mix of long experience and early carrier scientists, will be able to mark an imprint that makes JCMLRI a lead research institute in India with global impact. That will be the right way to live up to the dreams of John, the perennial traveler pursuing medical solutions that reaches everybody in the world.
Dr. Debasree Bishnu is currently a Senior Scientist of John C Martin Centre for Liver Research & Innovations with more than 10 years of experience in cell biology research. She has done her Bachelor's in Microbiology from Bangalore University, Bangalore, followed by a Post-Graduation in Biochemistry from the same university. She further holds a Ph.D. in Biological Sciences from Institute of Post Graduate Medical Education & Research (IPGME&R) Kolkata during 2011-2016. She has expertise in a wide range of scientific research. She is skilled in the use of laboratory instruments and equipment. She served as Junior Researcher during 2018-2021 under IILDS-Medgenome collaborated project.
View DetailsDr. Bishnu has knowledge in the field of cell biology. She has performed experimental design and data analysis for a variety of research projects. Assisted in the design and implementation of various laboratory protocols. She has conducted extensive research into the fields of liver cell injury.
Dr. Chatterjee, with her background in Genomics, has focused on genomic alterations associated with complex disorders, particularly metabolic disorders and cancers. She identified specific genomic alterations linked to an elevated risk of non-alcoholic fatty liver disease (NAFLD), notably among lean individuals. Using transcriptomic data, she identified NAFLD progression biomarkers and uncovered the link between insulin signaling dysfunction and disease pathophysiology. Her postdoctoral work explored immune contextures in oral squamous cell carcinoma and their implications for immunotherapy, identifying a potential metabolite biomarker for OSCC prognosis. This research emphasizes the significance of immune contextures for personalized cancer treatment. She also contributed to understanding ethnic variations in peripheral immune responses. At JCMLRI, she is analyzing the interplay of immune irregularities and metabolic adjustments in lean NASH patients with advanced fibrosis through single-cell transcriptomics.
View Details
- Project Manager, International Cancer Genome Consortium | July 2022 to March 2023
Organization: National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal, India, PIN: 741251
- Experimental Laboratory Manager, Systems Medicine Cluster| September 2018 to July 2022
Organization: National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal, India, PIN: 741251
- Technical Specialist, Systems Medicine Cluster| September 2018 to July 2022
Organization: National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal, India, PIN: 741251
1. Systems Medicine Cluster funded by Department of Biotechnology, Govt. Of India- SyMeC is a multi-institutional project involving six academic institutions in Kolkata, funded by DBT, Govt. Of India. SyMeC focused on the study of the pathogenesis of OSCC-GB, through a systemic approach. The project multi-omics high throughput data on cancer samples and aimed to design a molecular marker panel for OSCC-GB. Job responsibilities: Project co-ordination and management, Sample recruitment, Data generation, Analysis, Manuscript preparation.
2. International Cancer Genome Consortium (ICGC) -ICGC has been launched to coordinate large-scale cancer genome studies in tumors from 50 different cancer types that are of clinical and societal importance across the globe. The Indian initiative of the ICGC is on gingivo-buccal oral cancer (GBOC). Job responsibilities: Project co-ordination and management, Training, Manuscript preparation.
3. Asian Immune Diversity Atlas (AIDA)- in collaboration with Singapore Genome Institute, funded by Chan- Zukerberg Initiative. The project focuses on the profiling of diverse immune cells among healthy multi-ethnic individuals at a single cell resolution. Job responsibilities: Project co-ordination and management, Sample recruitment, Data generation, Analysis, Manuscript preparation.
4. Pediatric Networks for the Human Cell Atlas – Involved in the study of natural immune landscape of the nasopharyngeal tracts of children at a single cell resolution. The project is funded by Chan- Zukerberg Initiative. Job responsibilities: Project co-ordination and management, Sample recruitment, Data generation, Data analysis.
1. Continuous communication with clinical partners for biospecimen collection. Managing the process of proper storage facility and transport of biospecimens with patient phenotype data.
2. Monthly preparation of project updates and presentation. Tracking the PERT chart, organization of team meetings, priority-based experiment planning, quality check, and delivery of data analysis reports. Regular submission of project updates to clinical and research partners including updates on sample collection, data entry, data generation and data analysis.
3. Conduct regular quality control on data generation and analysis. Removal of biospecimen with poor data, revision on data generation failure, upgradation of SOPs, retrieval of missing data from clients and exclusion of low-quality data.
4. Implementation of data analysis algorithm, implementation of statistical methods for data analytics.
5. Continuous knowledge upgradation through self-learning via attending webinars, online courses. Sharing of knowledge with team members through regular team-meeting and organization of group-learning activities through shared resources.
6. Updating the team with new developments in data generation technology and laboratory experiments, collation of widely used SOPs across laboratories and implementation, one-to-one conversation with team members with problem solving.
7. Actively engaged in project report preparation and manuscript preparation.
1. Trained and certified in Good Laboratory Practices (basic course).
2. Nucleic acid isolation (DNA/RNA) from a range of biospecimens (fresh frozen tissues, FFPE tissues, blood, urine).
3. Single cell extraction from blood, tissue and swab samples.
4. NGS library preparation- bulk RNA-seq, Whole genome sequencing, Exome-seq, TCR-seq
5. Single cell Library preparation- ss RNA-seq, TCR-seq, BCR-seq, ATAC-seq
6. Usage of sequencing platforms- HiSeq2500, NovaSeq and MiSeq
7. Microarray experiments- Exome, Transcriptome, Methylome
8. Immunohistochemistry, FACS, Histopathology.
1. Raw data processing and Quality control, processing and analysis of high-throughput transcriptome data, whole-genome data and methylome data.
2. Proficient in R and Python.
3. Efficient in operating systems including WINDOWS and LINUX.
4. Microsoft OFFICE (Word, Excel, PowerPoint).
5. Processing of genotype data and quality control, population structure, relatedness, GWAS/EWAS, QTLs.
6. Somatic mutations calling, differential gene expression, differential methylation, immune repertoire diversity, neoantigen estimation, cell proportion estimation using deconvolution methods, survival analysis, hierarchical clustering, PCA.
7. Database searches and bioinformatic analysis on effects of SNP on protein structure, gene-gene interactions, pathway enrichment, regulation of gene-expression from integrative analysis of transcriptome, methylome and genome data.
8. Analysis of immune repertoire data and estimation of clonotypes, diversity.
9. Analysis of single cell sequencing data including single cell gene expression data processing, QA/QC, cell annotation, pseudobulk RNA-seq, single cell repertoire analysis, scATAC data.
Throughout my Ph.D. and post-doctorate research, I have collaborated with multiple clinicians. I am involved in co-ordinating with the clinicians for disease phenotype definition, patient recruitment and consent collection, non-invasive diagnosis (USG, MRS), sample collection and processing and follow-up.
National Post Doctoral Symposium, 2023. 12-14 Oct. 2023. Title: Unveiling the Impact of Freeze-Thaw Cycles on Single Cell Data Generation: A Comprehensive Study.
DST-SERB-sponsored High-End Workshop on Next Generation Sequence Data Analysis in Human Diseases, jointly conducted by MZU and NIBMG. 17 - 22 Oct. 2022. Title: An introduction to single cell RNA-seq: data generation and processing.
ONLINE INTERNATIONAL TRAINING WORKSHOP ON SINGLE CELL TRANSCRIPTOMICS, ORGANIZED BY: National Institute of Biomedical Genomics, Kalyani & Massachusetts Institute of Technology, Boston January 17-22,22. Title: Visualization of single cell RNA-seq data using Loupe Browser and Seurat.
Asian Immune Diversity Atlas, Annual Meet, 2022, 03 - 04 November 2022. Understanding Human Disease and Improving Human Health Using Genomics-Driven Approaches'.
1. SITC 37th Annual Meeting, held November 10-12, 2022, in Boston, MA. Title: Gingivo-buccal oral cancer: Inferring prognosis from immune contextures of tumor and surrounding margin. Abstract Number: 955.
2. TCGA India conference, 2019. Title: HPV infection and study of the polarity of Tumor-Associated Macrophages in Head and Neck Squamous Cell carcinoma using bulk RNA-seq data from TCGA. Best Poster Award.
3. 38th Annual conference of Indian Society of Human Genetics: Genomics and Community Health, 2012, India. Title: Molecular Anatomy of Non-Alcoholic Fatty Liver Disease (NAFLD) associated markers in the Indian Population.
4. American Society of Human Genetics, 66th Annual Meeting, 2016 at Vancouver, Canada. Presentation: POSTER. Title: Integrated Transcriptomic and Methylome analyses identify novel genes involved in progression of Non-alcoholic Fatty Liver Disease (NAFLD) among Indians (Abstract number: 1601201732). Awards: International Travel Award, DST-SERB, Government of India.
5. 27th Annual Conference of Asian Pacific Association for the Study of Liver, 2018, New Delhi. Title 1: Exome-wide association study with hepatic fat content in Non-alcoholic Fatty Liver Disease reveals significant association with 5 novel QTLs. Title 2: Liver transcriptome study and its relation to clinicopathological features identify insulin resistance as a key player in the early stages of NAFLD among Indians.
6. 37th Indian Association of Cancer Research Annual Meeting 2018. Title: “Functional genomics identified novel tumor suppressor genes Cavin3 to be associated with the deregulation of EGFR and IGF1R pathways during development of cervical squamous cell carcinoma in Indian patients.”
7. 37th Indian Association of Cancer Research Annual Meeting 2018. Title: “Enrichment of molecular transport pathways identified by genome wide CpG methylation screening in Pancreatic Ductal Adenocarcinoma patients in Eastern India.”
Chatterjee A, Chaudhary A, Ghosh A, Arun P, Mukherjee G, Arun I, Maitra A, Biswas N, Majumder PP. Overexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues. Cancer Med. 2023 Jul 1. doi: 10.1002/cam4.6299. PMID: 37392167. IF:4.7
Chatterjee A, Bararia A, Ganguly D, Mondal PK, Roy P, Banerjee S, Ghosh S, Gulati S, Ghatak S, Chattopadhay BK, Basu P, Chatterjee A, Sikdar N. DNA methylome in pancreatic cancer identified novel promoter hyper-methylation in NPY and FAIM2 genes associated with poor prognosis in Indian patient cohort. Cancer Cell Int. 2022 Nov 3;22(1):334. doi: 10.1186/s12935-022-02737-1. PMID: 36329447; PMCID: PMC9635159. IF:6.436
Chatterjee A, Basu P. Immune dysregulation in nonalcoholic steatohepatitis. InNutrition and Functional Foods in Boosting Digestion, Metabolism and Immune Health 2022 Jan 1 (pp. 99-113). Academic Press. IF:NA
Chatterjee A, Basu A, Das K, Chowdhury A, Basu P. Exome-wide scan identifies significant association of rs4788084 in IL27 promoter with increase in hepatic fat content among Indians. Gene. 2021 Jan 11:145431. doi: 10.1016/j.gene.2021.145431. PMID: 33444683. IF:3.91
Teo K, Abeysekera KWM, .., Chatterjee A, .. Young KA, Mann JP. rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis. J Hepatol. 2021 Jan;74(1):20-30. doi: 10.1016/j.jhep.2020.08.027. Epub 2020 Aug 31. PMID: 32882372; PMCID: PMC7755037. IF:30.08
Chatterjee A,, Basu A, Das K, et al. Hepatic transcriptome signature correlated with HOMA-IR explains early Nonalcoholic Fatty Liver Disease pathogenesis. Ann Hepatol. 2020; S1665-2681(20)30070-3. PMID: 32682086. IF:3.38
Chhatriya, B., Paine, S.K., Das, S., Chatterjee, A., Nath, D., Mukherjee, A., Basu, A. and Goswami, S., 2020. Single nucleotide polymorphisms in PRSS1 and CASR genes are associated with chronic pancreatitis in North-Eastern region of India. Journal of Gastrointestinal and Liver Diseases: JGLD, 29(2), pp.267-268. PMID: 32530995. IF:2.14
Roychowdhury A, Samadder S, Das P, Mazumder DI, Chatterjee A,, Addya S, Mondal R, Roy A, Roychoudhury S, Panda CK. Deregulation of H19 is associated with cervical carcinoma. Genomics. 2020 Jan 1;112(1):961-70. PMID: 31229557. IF:4.31
Roy N, Dasgupta D, Mukhopadhyay I, Chatterjee A,, Das K, Bhowmik P, Das S, Basu P, Santra AK, Datta S, Dhali GK, Chowdhury A, Banerjee S. Genetic Association and Gene-Gene Interaction Reveal Genetic Variations in ADH1B, GSTM1 and MnSOD Independently Confer Risk to Alcoholic Liver Diseases in India. PLoS One. 2016 Mar 3;11(3):e0149843. PMID: 26937962. IF:3.75
Biswas NK, Chandra V, Sarkar-Roy N, Das T, Bhattacharya RN, Tripathy LN, Basu SK, Kumar S, Das S, Chatterjee A,, Mukherjee A, Basu P, Maitra A, Chattopadhyay A, Basu A, Dhara S. Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM. Sci Rep. 2015 Jan 21;5:7915. PMID: 25604826. IF:4.99
Chatterjee A,, Basu A, Chowdhury A, Das K, Sarkar-Roy N, Majumder PP, Basu P. Comparative analyses of genetic risk prediction methods reveal extreme diversity of genetic predisposition to nonalcoholic fatty liver disease (NAFLD) among ethnic populations of India. J Genet. 2015 Mar;94(1):105-13. PMID: 25846882. IF:1.508
Chatterjee A,¥, Mondal B¥, Das K, Mondal D, Ghosh R, Chowdhury A, Basu P. In-depth sub-phenotyping identified association of lower bone mineral content, higher liver damage and SNPs in PDXDC1 and TTC39B genes with Non-alcoholic fatty liver disease combined with metabolic dysfunction. (Under review).
Shaikh S; Basu S; Bag S; Chatterjee A,; Datta S; Banerjee D; Manikantan K; Arun I; Arun P; Biswas NK; Maitra A; Mishra DK; Majumder PP; Dhar H; Mukherjee G. Uracil as a Biomarker for Spatial Pyrimidine Metabolism in the Development of Gingivobuccal Oral Squamous Cell Carcinoma. (Under review).